Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms
Identifieur interne : 000B36 ( Main/Exploration ); précédent : 000B35; suivant : 000B37Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms
Auteurs : Qian Xie [République populaire de Chine] ; Yujuan Cao [République populaire de Chine] ; Juan Su [République populaire de Chine] ; Jie Wu [République populaire de Chine] ; Xianbo Wu [République populaire de Chine] ; Chengsong Wan [République populaire de Chine] ; Mingliang He [République populaire de Chine] ; Changwen Ke [République populaire de Chine] ; Bao Zhang [République populaire de Chine] ; Wei Zhao [République populaire de Chine]Source :
- Archives of Virology [ 0304-8608 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Analyse de séquence d'ADN, Biologie informatique, Cadres ouverts de lecture, Chine, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Délétion de gène, Fièvre (virologie), Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Partie nasale du pharynx (virologie), Protéines de l'enveloppe virale (génétique), Toux (virologie), Variation génétique, Voyage.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Protéines de l'enveloppe virale.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus.
- virologie : Fièvre, Infections à coronavirus, Partie nasale du pharynx, Toux.
- Adulte, Analyse de séquence d'ADN, Biologie informatique, Cadres ouverts de lecture, Chine, Délétion de gène, Humains, Variation génétique, Voyage.
English descriptors
- KwdEn :
- Adult, China, Computational Biology, Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Cough (virology), Fever (virology), Gene Deletion, Genetic Variation, Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Nasopharynx (virology), Open Reading Frames, Sequence Analysis, DNA, Travel, Viral Envelope Proteins (genetics).
- MESH :
- chemical , genetics : Viral Envelope Proteins.
- drug therapy : Coronavirus Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Cough, Fever, Nasopharynx.
- Adult, China, Computational Biology, Gene Deletion, Genetic Variation, Humans, Open Reading Frames, Sequence Analysis, DNA, Travel.
Abstract
Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated.
The online version of this article (doi:10.1007/s00705-017-3361-x) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s00705-017-3361-x
PubMed: 28421366
PubMed Central: 5506503
Affiliations:
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7471</institution-id><institution-id institution-id-type="GRID">grid.284723.8</institution-id><institution>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health,</institution><institution>Southern Medical University,</institution></institution-wrap>No. 1023 Shatai Road, Guangzhou, 510515 People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>No. 1023 Shatai Road, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8877 7471</institution-id><institution-id institution-id-type="GRID">grid.284723.8</institution-id><institution>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health,</institution><institution>Southern Medical University,</institution></institution-wrap>Guangzhou, 510515 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="He, Mingliang" sort="He, Mingliang" uniqKey="He M" first="Mingliang" last="He">Mingliang He</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1792 6846</institution-id><institution-id institution-id-type="GRID">grid.35030.35</institution-id><institution>Department of Biomedical Sciences,</institution><institution>City University of Hong Kong,</institution></institution-wrap>Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Ke, Changwen" sort="Ke, Changwen" uniqKey="Ke C" first="Changwen" last="Ke">Changwen Ke</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8803 2373</institution-id><institution-id institution-id-type="GRID">grid.198530.6</institution-id><institution>Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Research Center for Pathogens Detection Technology of Emerging Infectious Diseases,</institution><institution>Guangdong Provincial Center for Disease Control and Prevention,</institution></institution-wrap>Guangzhou, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Bao" sort="Zhang, Bao" uniqKey="Zhang B" first="Bao" last="Zhang">Bao Zhang</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8877 7471</institution-id><institution-id institution-id-type="GRID">grid.284723.8</institution-id><institution>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health,</institution><institution>Southern Medical University,</institution></institution-wrap>No. 1023 Shatai Road, Guangzhou, 510515 People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>No. 1023 Shatai Road, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8877 7471</institution-id><institution-id institution-id-type="GRID">grid.284723.8</institution-id><institution>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health,</institution><institution>Southern Medical University,</institution></institution-wrap>Guangzhou, 510515 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name><affiliation wicri:level="3"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8877 7471</institution-id><institution-id institution-id-type="GRID">grid.284723.8</institution-id><institution>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health,</institution><institution>Southern Medical University,</institution></institution-wrap>No. 1023 Shatai Road, Guangzhou, 510515 People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>No. 1023 Shatai Road, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8877 7471</institution-id><institution-id institution-id-type="GRID">grid.284723.8</institution-id><institution>Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Public Health,</institution><institution>Southern Medical University,</institution></institution-wrap>Guangzhou, 510515 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou</wicri:regionArea></affiliation></author></analytic><series><title level="j">Archives of Virology</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>China</term><term>Computational Biology</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (virology)</term><term>Cough (virology)</term><term>Fever (virology)</term><term>Gene Deletion</term><term>Genetic Variation</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Nasopharynx (virology)</term><term>Open Reading Frames</term><term>Sequence Analysis, DNA</term><term>Travel</term><term>Viral Envelope Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Analyse de séquence d'ADN</term><term>Biologie informatique</term><term>Cadres ouverts de lecture</term><term>Chine</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Délétion de gène</term><term>Fièvre (virologie)</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Partie nasale du pharynx (virologie)</term><term>Protéines de l'enveloppe virale (génétique)</term><term>Toux (virologie)</term><term>Variation génétique</term><term>Voyage</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Protéines de l'enveloppe virale</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Fièvre</term><term>Infections à coronavirus</term><term>Partie nasale du pharynx</term><term>Toux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Cough</term><term>Fever</term><term>Nasopharynx</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>China</term><term>Computational Biology</term><term>Gene Deletion</term><term>Genetic Variation</term><term>Humans</term><term>Open Reading Frames</term><term>Sequence Analysis, DNA</term><term>Travel</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Analyse de séquence d'ADN</term><term>Biologie informatique</term><term>Cadres ouverts de lecture</term><term>Chine</term><term>Délétion de gène</term><term>Humains</term><term>Variation génétique</term><term>Voyage</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1007/s00705-017-3361-x) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A Bermingham</name></author><author><name sortKey="Chand, Ma" uniqKey="Chand M">MA Chand</name></author><author><name sortKey="Brown, Cs" uniqKey="Brown C">CS Brown</name></author><author><name sortKey="Aarons, E" uniqKey="Aarons E">E Aarons</name></author><author><name sortKey="Tong, C" uniqKey="Tong C">C 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Koch, R" uniqKey="Mozes Koch R">R Mozes-Koch</name></author><author><name sortKey="Gantman, Y" uniqKey="Gantman Y">Y Gantman</name></author><author><name sortKey="Peretz, Y" uniqKey="Peretz Y">Y Peretz</name></author><author><name sortKey="Edelbaum, O" uniqKey="Edelbaum O">O Edelbaum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nieto Torres, Jl" uniqKey="Nieto Torres J">JL Nieto-Torres</name></author><author><name sortKey="Dediego, Ml" uniqKey="Dediego M">ML Dediego</name></author><author><name sortKey="Alvarez, E" uniqKey="Alvarez E">E Alvarez</name></author><author><name sortKey="Jimenez Guarde O, Jm" uniqKey="Jimenez Guarde O J">JM Jiménez-Guardeño</name></author><author><name sortKey="Regla Nava, Ja" uniqKey="Regla Nava J">JA Regla-Nava</name></author><author><name sortKey="Llorente, M" uniqKey="Llorente M">M Llorente</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westerbeck, Jw" uniqKey="Westerbeck J">JW Westerbeck</name></author><author><name sortKey="Machamer, Ce" uniqKey="Machamer C">CE Machamer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Xie, Qian" sort="Xie, Qian" uniqKey="Xie Q" first="Qian" last="Xie">Qian Xie</name></region><name sortKey="Cao, Yujuan" sort="Cao, Yujuan" uniqKey="Cao Y" first="Yujuan" last="Cao">Yujuan Cao</name><name sortKey="Cao, Yujuan" sort="Cao, Yujuan" uniqKey="Cao Y" first="Yujuan" last="Cao">Yujuan Cao</name><name sortKey="He, Mingliang" sort="He, Mingliang" uniqKey="He M" first="Mingliang" last="He">Mingliang He</name><name sortKey="Ke, Changwen" sort="Ke, Changwen" uniqKey="Ke C" first="Changwen" last="Ke">Changwen Ke</name><name sortKey="Su, Juan" sort="Su, Juan" uniqKey="Su J" first="Juan" last="Su">Juan Su</name><name sortKey="Wan, Chengsong" sort="Wan, Chengsong" uniqKey="Wan C" first="Chengsong" last="Wan">Chengsong Wan</name><name sortKey="Wan, Chengsong" sort="Wan, Chengsong" uniqKey="Wan C" first="Chengsong" last="Wan">Chengsong Wan</name><name sortKey="Wu, Jie" sort="Wu, Jie" uniqKey="Wu J" first="Jie" last="Wu">Jie Wu</name><name sortKey="Wu, Xianbo" sort="Wu, Xianbo" uniqKey="Wu X" first="Xianbo" last="Wu">Xianbo Wu</name><name sortKey="Wu, Xianbo" sort="Wu, Xianbo" uniqKey="Wu X" first="Xianbo" last="Wu">Xianbo Wu</name><name sortKey="Xie, Qian" sort="Xie, Qian" uniqKey="Xie Q" first="Qian" last="Xie">Qian Xie</name><name sortKey="Zhang, Bao" sort="Zhang, Bao" uniqKey="Zhang B" first="Bao" last="Zhang">Bao Zhang</name><name sortKey="Zhang, Bao" sort="Zhang, Bao" uniqKey="Zhang B" first="Bao" last="Zhang">Bao Zhang</name><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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